Publication Summaries

The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma

Authors: Rachna Ram, Helen D. Brasch, Jonathan C. Dunne, Paul F. Davis, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery – Otorhinolarynology – Head and Neck Surgery Surgery, Front Surg 2017; 4:

http://dx.doi.org/10.3389/fsurg.2017.000412

Cancers of the lip are found with relatively similar levels of incidence throughout the world. The incidence is higher in males (between 12 and 13.5 per 100,000 population) but the frequency in females is increasing. It is usually treated with surgery, radiotherapy or both.

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Cancer Stem Cell Hierarchy in Glioblastoma Multiforme

Authors: Amy Bradshaw, Agadha Wickremsekera, Swee T. Tan, Lifeng Peng, Paul F. Davis and Tinte Itinteang

Frontiers in Surgery – Neurosurgery, Front Surg 2016;3:21

http://journal.frontiersin.org/article/10.3389/fsurg.2016.00021

This paper is a review of the current knowledge and understanding of the cause of glioblastoma multiforme (GBM), a type of brain cancer.

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Cancer Stem Cells in Glioblastoma Multiforme

Authors: Amy Bradshaw, Agadha Wickremesekera, Helen D. Brasch, Alice M. Chibnall, Paul F. Davis, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery – Neurosurgery, Front Surg 2016;3:48

http://journal.frontiersin.org/article/10.3389/fsurg.2016.00048

Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumour. It has a five-year survival of only 2%, despite intensive research. It frequently recurs following surgical resection, radiotherapy and chemotherapy. This poor prognosis has been attributed to the initiation, propagation and differentiation of cancer stem cells (CSCs).

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Glioblastoma Multiforme Cancer Stem Cells Express Components of the Renin-Angiotensin System

Authors: Amy R. Bradshaw, Agadha C. Wickremesekera, Helen D. Brasch, Alice M. Chibnall, Paul F. Davis, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery – Neurosurgery, Front Surg 2016;3:51

http://journal.frontiersin.org/article/10.3389/fsurg.2016.00051

Glioblastoma multiforme (GBM) is a brain cancer that constitutes 60-70% of all malignant gliomas. This poor prognosis has been ascribed to the presence of cancer stem cells (CSCs) within the GBM. These CSCs multiply and form cancer cells that make up the bulk of the tumour. The CSCs are resistant to chemotherapy and radiotherapy.

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Cancer Stem Cells in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma

Authors: Ranui Baillie, Tinte Itinteang, Helen H. Yu, Helen D. Brasch, Paul F. Davis and Swee T. Tan

Journal of Clinical Pathology, 2016;69:742-744

http://jcp.bmj.com/content/69/8/742.full?sid=0b72c4ed-b6af-4a90-83bf-b8a3263fc86a

Cancers of the mouth are the sixth most common type of cancer. Among these cancers those affecting the tongue is the most common. The main therapies for treating these are surgery and radiotherapy. The chance of survival following conventional treatments is only 50%, which has remained unchanged for more than 40 years.

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Cancer Stem Cells in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

Authors: Tinte Itinteang, Jonathan C. Dunne, Alice M. Chibnall, Helen D. Brasch, Paul F. Davis and Swee T. Tan

 Journal of Clinical Pathology, 2016;69:942-945

http://jcp.bmj.com/content/69/8/742.full?sid=0b72c4ed-b6af-4a90-83bf-b8a3263fc86a

Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the mouth. In a previous publication we identified two distinct subpopulations of cancer stem cells (CSCs) within tongue cancers, distributed within different areas of the tumour.

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Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma

Authors: Helen H. Yu, Therese Featherston, Swee T. Tan, Alice M. Chibnall, Helen D. Brasch, Paul F. Davis and Tinte Itinteang

Frontiers in Surgery – Plastic and Reconstructive Surgery, Front Surg 2016;3:46

http://dx.doi.org/10.3389/fsurg.2016.00046

Cancers in the mouth are the sixth most common cancer worldwide, with over 90% being squamous cell carcinoma (SCC). SCCs affect the tongue, the floor of the mouth, the inner cheek region, the hard palate and the jaw.

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Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

Authors: Therese Featherston, Helen H. Yu, Jonathan C. Dunne, Alice M. Chibnall, Helen D. Brasch, Paul F. Davis, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery – Plastic & Reconstructive Surgery, Front Surg 2016; 3:52

http://journal.frontiersin.org/article/10.3389/fsurg.2016.00052

Cancer of the mouth is the sixth most common cancer world-wide. Those that affect the inside of the cheek (known as buccal mucosal squamous cell carcinoma, BMSCC) are particularly aggressive.

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