Expression and Localisation of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma

Authors: Therese Featherston, Reginald Marsh, Bede van Schaijik, Helen D. Brasch, Swee T. Tan and Tinte Itinteang

Frontiers in Medicine. July 2017. Volume 4, Article 100  doi: 10.3389/fmed.2017.00100


The GMRI has previously demonstrated the putative presence of two cancer stem cell (CSC) subpopulations within moderately differentiated oral tongue squamous cell carcinoma (MDOTSCC), which express components of the renin–angiotensin system (RAS).

In this study we investigated the expression and localisation of the proteases cathepsins B, D, and G in relation to these CSC subpopulations within MDOTSCC.

We identified the presence of cathepsins B and D in the CSCs and cathepsin G on what are phenotypically mast cells. The identification of these suggests the presence of bypass loops for the RAS. Consistent with our other findings with respect to the control of the RAS, this represents an additional area of regulation as part of a novel therapeutic target for MDOTSCC.

Renin-angiotensin System and Cancer: A Review

Authors: Matthew J. Munro, Agadha C. Wickremesekera, Paul F. Davis, Reginald Marsh, Swee T. Tan and Tinte Itinteang

Integrative Cancer Science and Therapeutics. March 2017. Vol.4: doi:10.15761/ICST:1000231

There are numerous reports showing that cancer patients who are treated with medications that control the renin-angiotensin system, such as anti-hypertension drugs, have better survival from cancer and a lower risk of developing cancer.

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Expression of Cathepsins B, D, and G in Isocitrate Dehydrogenase-Wildtype Glioblastoma

Authors: Sabrina P. Koh, Agadha C. Wickremesekera, Helen D. Brasch, Reginald Marsh, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery, May 2017. Vol.4. doi:10.3389/surg.2017.00028

The GMRI has demonstrated the presence of cancer stem cells – considered to be the origin of cancer – in many different types of cancers including glioblastoma, the most aggressive form of brain cancer. We have also shown that the cancer stem cells in glioblastoma possess the constituents of the renin-angiotensin system.

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Cancer Stem Cells in Moderately Differentiated Lip Tongue Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

Authors: Rachna S. Ram, Helen D. Brasch, Jonathan C. Dunne, Paul F. Davis, Swee T. Tan and Tinte Itinteang

Frontiers in Surgery – Otorhinolaryngology – Head and Neck Surgery June 2017. Vol.4: doi:10.3389 /fsurg. 2017.00030

Earlier research undertaken by the team at the Gillies McIndoe Research Institute has identified and characterised cancer stem cells in tongue cancer, buccal mucosal (inner cheek) cancer, and lip cancer. The team has also shown that cancer stem cells in tongue cancer and buccal mucosal cancer express the renin-angiotensin system.

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GMRI scientists give keynote addresses at the 10th International Conference on Cancer Stem Cells and Oncology Research

Executive Director Dr Swee Tan and Chief Scientific Officer Dr Tinte Itinteang recently returned from London where they delivered two keynote addresses at the 10th International Conference on Cancer Stem Cells and Oncology Research.

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GMRI to host lecture by top Australian plastic surgeon and stem cell researcher

Professor Wayne Morrison

The GMRI is pleased to announce that Australian Professor Wayne Morrison will be giving a public lecture in Wellington as part of the GMRI Eminent Speakers’ Programme.

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College students raise funds for glioblastoma research

From left: Dr Tinte Itinteang, Olivia Watson, Phoebe Ellis, Dr Agadha Wickremesekera, Dr Paul Davis

Staff at the GMRI received a special visit this month from Queen Margaret College student Phoebe Ellis, who has raised close to $1000 towards the GMRI’s glioblastoma (GB) research programme.

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GMRI scientists lead the way in solving crippling hand disease

Sabrina Koh,
Deane Endowment Trust
sponsored summer student

People suffering from Dupuytren’s disease could ultimately regain the function of their hands and quality of life, thanks to the international award winning work of the GMRI.

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Sir Harold Gillies’s pioneering work recognised as part of Passchendaele commemorations

Sir Harold Gillies

The pioneering work of Sir Harold Gillies, whom the Gillies McIndoe Research Institute is co-named after, has been recognised by the UK’s Daily Mail as part of the commemorations of the battle of Passchendaele.

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GMRI joins social media

The GMRI is making improvements in how we communicate with our friends and supporters, by joining Facebook and Twitter.

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