Subcellular Localization of the Stem Cell Markers OCT4, SOX2, NANOG, KLF4 and c-MYC in Cancer: A Review

Authors: Bede van Schaijik, Paul F. Davis, Agadha C. Wickremesekera, Swee T. Tan and Tinte Itinteang

Journal of Clinical Pathology 2018. Volume 71, 88-91
doi:10.1136/j.jclinpath-2017-204815
http://jcp.bmj.com/content/71/1/88

The cancer stem cell (CSC) concept of cancer proposes that not all cancer cells participate in tumour formation and that the development and progression of cancer is driven by CSCs, a small sub-population of cells. A number of molecules specific to stem cells have been identified.

This review summarises the current understanding of the localisation and function of these molecules in relation to the role of cancer stem cells for a number of types of cancer. These findings give clues relating to their roles in cancer development and growth. They are found both inside and outside the nuclei of cells, which suggest that their movement in the cells may determine their functional activities with regards to tumour proliferation.

GMRI and HVDHB to jointly host public lecture by leading plastic and craniofacial surgeon and medical humanitarian

Dr Mark Moore

Dr Moore is a plastic and craniofacial surgeon and medical humanitarian. He is the Head of the Australian Craniofacial Unit in Adelaide, Australia, where he has spent the last 30 years of his career after completing his plastic surgical training in New Zealand. During this time he has been actively involved in multidisciplinary clinical management, teaching and research into a wide array of major cleft and craniofacial anomalies.
He has participated in the development of craniofacial surgical services within the South East Asian region through an involvement in outreach clinics and teaching.

Over the last 18 years Dr Moore has had a major commitment to the provision and development of cleft lip and palate and reconstructive plastic surgical services in the eastern Indonesian provinces and Timor-Leste, for which he was recognised by being awarded a Member of the Order of Australia (AM) by the Australian Government, as well as the Royal Australasian College of Surgeons International Medal. In the last three years he has also contributed to similar surgical service provision in Bhutan, working with Interplast.

Dr Moore’s lecture will be held at:
5.00 pm Thursday 8 March
James Coe Centre, Dowse Art Museum
45 Laings Road, Lower Hutt

The lecture is open to the public. Seats are limited so if you would like to attend please click here.

Tumour Stem Cells in Meningioma: A Review

Authors: Ganeshwaran Shivapathasundram, Agadha C. Wickremesekera, Swee T. Tan and Tinte Itinteang

Journal of Clinical Neuroscience 2018. Volume 47, 66-71 doi:10.1016/j.jocn.2017.10.059

https://www.researchgate.net/publication/320859474_Tumour_stem_cells_in_meningioma_A_review

Meningiomas are cancers that occur in the brain and spinal cord. They comprise about 25% of all neurological cancers. Their incidence is around 6 per 100,000 with a slightly higher preponderance in females. While the majority of these cancers are benign, they have a high rate of recurrence especially when the location is at the base of the skull.

The presence of stem cells in meningioma was first reported in 2009 in an aggressive malignant form. This review discusses the identification of a number of stem cell marker proteins in this tumour so as to establish a possible hierarchy of them. However it is apparent that there is relatively little known at this stage about the properties and functions of these cells in meningiomas and that further studies are needed.

Top plastic surgeon and stem cell researcher calls GMRI cancer research “extraordinary”

Dr Swee Tan, Professor Wayne Morrison, Mayor Justin Lester, Chair Paul Baines

In August the GMRI was honoured to host top plastic surgeon and stem cell researcher, Professor Wayne Morrison, as part of the GMRI Eminent Speakers’ Programme.

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GMRI to host public lecture by Harvard Medical School expert in vascular birthmarks

Associate Professor Arin Greene

The GMRI is pleased to host a further public lecture in December as part of the GMRI Eminent Speakers’ Programme.

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Capital & Coast District Health Board and the GMRI team up on glioblastoma research

CCDHB neurosurgeon and GMRI Honorary Research Associate, Dr Agadha Wickremesekera

Researchers from the GMRI and neurosurgeons from Capital & Coast DHB have joined forces to tackle glioblastoma (GB), the most aggressive primary cancer of the brain.

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Sharing our research and plans with funders and supporters

Dr Swee Tan, PHARMAC communications manager Kerri Osborne and CEO Steffan Crausaz, Chair Paul Baines

During the past few months the GMRI has welcomed a number of VIP’s to our Newtown laboratories, including Steffan Crausaz, CEO of PHARMAC, CEO of the Health Research Council, Professor Kathryn McPherson, and Singapore-based businessman and innovator Robert Yap.  

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Generous donation from Plimmerton Rotary Club will “supercharge” stem cell research

Club President Graeme Blick, Dr Swee Tan and Dr Tinte Itinteang

In August, GMRI Executive Director Dr Swee Tan and Chief Scientific Officer Dr Tinte Itinteang were guests of the Plimmerton Rotary Club, where they were presented with a significant donation for our cancer stem cell research.

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Embryonic Stem Cell-Like Population in Venous Malformation

Authors: Elysia M.S. Tan, Sam D. Siljee, Helen D. Brasch, Susana Enriquez, Swee T. Tan and Tinte Itinteang

Frontiers in Medicine (Dermatology). October 2017. Doi:10.3389/fmed.2017.00162

https://www.frontiersin.org/articles/10.3389/fmed.2017.00162/full

Vascular malformations alter arteries, veins, capillaries and lymphatic vessels. The most common of these is venous malformation, which affects about 1% of the population. These malformations are composed of anomalous veins with thin walls and are present at birth but only become apparent later in life.

The cause of this condition is not well understood although a number of possibilities have been proposed. We have identified and characterised stem cells in this condition. The paper reports that there are two populations of these cells, one being part of the lining of the blood vessels, the other outside the lining.

The further characterisation of these primitive cells is the subject of ongoing research in the hope of identifying properties that might provide the opportunity of regulating and controlling them and the consequent development of these malformations.

GMRI to host public lecture by Harvard Medical School expert in vascular birthmarks

Assoc. Prof. Arin Greene

The GMRI is pleased to host a public lecture in December as part of the GMRI Eminent Speakers’ Programme.

The lecture, titled “Vascular Birthmarks: From Bedside to Bench and Back”, will be delivered by Assoc. Prof. Arin Greene, a paediatric plastic surgeon at Boston Children’s Hospital and Harvard Medical School.

Prof. Greene’s research is primarily focused on vascular birthmarks and lymphoedema. He has authored over 170 research papers and 100 book chapters, and has edited five books.

Dr Swee Tan says it is exciting to host a plastic surgeon and researcher of Prof. Greene’s calibre, and he and colleagues are looking forward to comparing research findings on vascular birthmarks, a field of research that the GMRI is actively involved in.

“As part of Prof. Greene’s visit we will be running a special vascular birthmarks clinic at Hutt Hospital in which we will be seeing patients with complex vascular birthmarks from around New Zealand. This clinic will be attended by specialists and trainees from Hutt Valley DHB and Capital & Coast DHB,” Dr Tan says.

Prof. Greene’s lecture will be held at 5pm Tuesday 5 December at Rutherford House Lecture Theatre, Pipitea Campus, Victoria University of Wellington.

The lecture is open to the public. Seats are limited so if you would like to attend please click here.